Case 48 - Discussion

Uploaded: 2008-02-07, Updated: 2008-02-07

 

 

CD3 CD20
CD5 CD7
CD15 CD30
   

Diffuse Large B-Cell Lymphoma, Anaplastic Type (CD30+)

Lymph node is completely effaced by large anaplastic lymphoid cells with irregular nuclear contour, prominent nucleoli and moderate to abundant cytoplasm. There are scattered large multinucleated atypical cells with frequent mitotic figures and numerous apoptotic bodies. Scattered eosinophils are present in the background. The tumor cells are positive for CD20 and CD30, but negative for ALK-1, CD15, CD3, CD4, CD5, CD7, CD8 and AE1/ AE3.

 

The Key Features

 

CLINICAL FEATURES

 

GROSS FINDINGS

 

MICROSCOPIC FINDINGS

 

SUBTYPES

 

DIFFERENTIAL DIAGNOSES

 

IMMUNOHISTOCHEMISTRY AND SPECIAL STAINS

 

ELECTRON MICROSCOPIC FINDINGS

 

CYTOGENETIC STUDIES

 

TREATMENT AND PROGNOSIS

 

REFERENCES