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§15-20% of all myeloma cases.
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§More malignant course compared to classic
myeloma.
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§Extremely rapid doubling time.
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§Tendency for more osteolytic lesions.
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§Increased hypercalcemia.
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§Higher incidence of renal failure
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§Higher incidence of amyloidosis and plasma cell
leukemia.
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§Renal failure, principle cause of death.
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§Lambda LCM has 3x worse prognosis than kappa
LCM.