Reactive paracortical hyperplasia with an
increased number of interdigitating dendritic cells, Langerhans
cells, and histiocytes with cytoplasmic melanin deposits and lipid
Mostly axillary and inguinal lymph nodes.
Associated with skin lesion.
Paracortical expansion, pale confluent areas
Increased histiocytes, interdigitating
dendritic cells (S100+, CD1a-), and Langerhans cells (S100+,
Phagocytic histiocytes with lipid, melanin,
or less often hemosiderin
Follicular hyperplasia present in early stage
DDX: mycosis fungoides and SÚzary syndrome
involving lymph node - similar morphology, partially or totally
obliterated architecture, flow cytometry or molecular studies