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Case 144 - Discussion

Uploaded: 2010-10-10, Updated: 2010-10-10

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    A large lymph node has both hyperplastic and atrophic follicles with prominent expansion of interfollicular areas. There are some features of Castleman disease. The interfollicular areas contain a mixed population of cells with marked increased vascularity. Many small lymphocytes are actively migrating out of the high endothelial venules with cuffing of these vessels. I wish they could tell me what's happening in this lymph node and what they are doing here.

    The patient had no history of HIV, and the lymph node was negative for EBV and HHV8 stains. Flow cytometry didn't show any monoclonal lymphocytes.