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Typically in kids or young adults with fever, lymphadenopathy and
splenomegaly
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Tonsil or lymph node with prominent interfollicular expansion by
polymorphous cells, including small lymphocyte, immunoblasts,
plasmacytoid cells, and plasma cells
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Atypical cells with immunoblatic or RS cell appearance may be
noted. Atypical cells may form large clusters, resembling large
cell lymphoma
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Necrosis
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Immunoblasts positive for CD30
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EBER-ISH highlights both large and small cells, whereas in
lymphoma, only large cells positive for EBER
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NEVER diagnose large cell lymphoma in the tonsil or
cervical lymph node of kids/young adults without serology studies
for viral infection
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