- Solitary type: a solitary mass composed of multiple discrete
lymph nodes
- Multicentric or systemic type:
- HIV associated
- Generalized adenopathy and involvement of spleen
- Systemic symptoms (fever, anemia) and laboratory
abnormalities (elevated erythrocyte sedimentation rate,
hypergammaglobulinemia or hypoalbuminemia)
- Seen in older individuals and is frequently aggressive
- Associated with the POEMS syndrome (polyneuropathy,
organomegaly, endocrinopathy, M protein and skin changes),
amyloid deposits
- HHV-8 infection
- Abundant expression of interleukin-6, responsible for the
plasma cell infiltration.
- Microscopically, the lymph nodes demonstrate extensive
architectural obliteration by sheets of plasma cells between
hyperplastic follicular centers; interfollicular vascular
proliferation; the sinuses are usually preserved; lack of
hyaline-vascular changes
- A reactive disorder may have monoclonal but polytypic plasma
cells
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