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Classic features of Sezary syndrome:
circulating Sezary cells, erythroderma, hyperkerotosis of the
palms and soles, lymphadenopathy
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Criteria for Sezary
syndrome: peripheral lymphocytosis, clonal T-cells in the
peripheral blood, elevated CD4/CD8 ration >10, abnormal
immunophenotype
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Sezary cells: medium in
size, larger than mature lymphocytes, ceribriform nuclei and scant
cytoplasm
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Typical
immunophenotype: CD3+, CD4+, CD8-, CD7-
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