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Case 213 - Discussion

Uploaded: 2011-09-22, Updated: 2011-09-22


Plasmacytoid dendritic cell nodule

  • Formerly called plasmacytoid monocytes
  • Location: paracortex, in clusters
  • Morphology:
    • Clusters, with tingible-body macrophages but no mantle zone
    • Medium size, round cell, well-defined cell borders
    • Cytoplasm: moderate, eosinophilic to faintly basophilic
    • Nucleus: round, oval or slightly indented, fine or vesicular chromatin
    • Nucleolus: 1-2, small
    • Frequent apoptosis and tingible-body macrophages
  • CD123+, CD68+, lysozyme+, CD11c-
  • DDX:
    • Reactive germinal center: CD21+ meshwork, mantle zone, a diversity of cells