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Case 237 - Discussion

Uploaded: 2011-11-05, Updated: 2011-11-05

 

CD2

CD3

CD20

CD8

CD4

CD4

CD43

CD43

CD30

CD30

Negative marker: cytokeratin

ALK

 

 

Implant-related primary anaplastic large cell lymphoma (ALCL) of the breast

  • Reported in both saline- and silicone-filled devices
  • Most cases (78%) ALK negative
  • Indolent clinical course
  • One reported case with  bilateral implant-related primary ALCL of the breast
  • Differential diagnosis: high-grade breast carcinoma, degenerative cells
Reference
  • Clin Breast Cancer. 2011 Oct;11(5):283-96. Epub 2011 May 11.
  • Leuk Lymphoma. 2011 Aug;52(8):1481-7. Epub 2011 Jun 24.
  • Cancer. 2011 Apr 1;117(7):1478-89. doi: 10.1002/cncr.25654. Epub 2010 Nov 8.
  • Am J Surg Pathol. 2008 Aug;32(8):1265-8.