-
Breakpoint junction:
core binding factor (CBFB) at 16q22 and smooth muscle myosin heavy
chain (MYH11) at 16q13
-
Blasts have
myelomonocytic features
-
Blasts positive for
CD34, CD117, granulocytic markers (CD13, CD33, CD15 and MPO), and
monocytic markers (CD4, CD11b, CD11c, CD14, CD64, CD36 and
lysozyme)
-
Aberrant CD2 expression
in a subset of cases
-
Abnormal eosinophils
with large, basophilic granules (so called "pizza" cells)
-
Favorable prognosis in
the absence of KIT mutations.
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