- Also called lymphoepithelioma
- Bimodal age distribution: in
teens and patients >50 years of age
- Commonly metastasize to cervical
lymph nodes, often as initial presentation
- Morphology
- Syncytial growth pattern of relatively uniform tumor cells
with indistinct cell margins
- Tumor cells are large in size and have vesicular
nuclei and prominent nucleoli. Tumor may contain spindle cells
and scattered effete (“worn out”) cells with shrunken,
hyperchromatic nuclei
- Usually contain abundant inflammatory cells, including
lymphocytes, plasma cells, eosinophils and macrophages; patterns
below may be mixed or with one cell type predominant (eosinophil
predominant in this case)
- EBER-ISH positive in almost all cases
- Treatment: radiotherapy and chemotherapy, 70-90%
5-year overall survival
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