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Immunophenotypic Profiles of B Cell Development |
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Uploaded: 2007-06-18, Updated: 2007-06-18 |
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Stem Cell |
Early Pro-B |
Late Pro-B |
Pre-B Large |
Pre-B Small |
Immature B Cell |
Mature Naive B |
Transition B Cell |
GC B Cell |
MZ B Cell |
B1 Cell |
Memory B Cell |
Plasma Cell |
|
DJH |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | + | ||
|
V-DJH |
− |
− | + |
+ |
+ |
+ |
+ |
+ |
+ |
+ | + | ||
|
VJL |
− |
− |
− |
− |
+ |
+ |
+ |
+ |
+ |
+ | + | ||
|
Pre-BCR |
− |
− |
− |
+c |
+cm |
− |
− |
− |
− |
− | − | ||
|
IgL |
− |
− |
− |
− |
+ |
+ |
+ |
+ |
+ |
+ | + | ||
|
IgM |
− |
− |
− |
− |
− |
+ |
+ |
+ |
+ |
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| IgD | − | − | − | − | − | − | + |
+ |
+ |
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|
SLC |
− |
+ |
+ |
+ |
− |
− |
− |
− |
− |
− | − | ||
|
Igαβ |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | + | ||
|
TdT |
− |
+ |
+ |
− |
+ |
+ |
− |
− |
|
− | − | ||
|
RAG1 |
− |
+ |
+ |
− |
+ |
+ |
− |
− |
− | − | |||
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RAG2 |
− |
+ |
+ |
− |
+ |
+ |
− |
− |
− | − | |||
|
BTK |
− |
+low |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | |||
|
KIT |
+ |
+low |
+low |
+low |
− |
− |
− |
− |
− |
− | − | ||
|
CD10 |
− |
+ |
+ |
+ |
+ |
+ |
− |
− |
|
− | − | ||
|
CD19 |
− |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | − | ||
|
CD20 |
− |
− |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ | − | ||
|
CD21 |
− |
− |
− |
− |
− |
− |
+ |
+ |
+ |
+ | − | ||
|
CD24 |
− |
+ |
+ |
+ |
+ |
+ |
+ |
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CD25 |
− |
− |
− |
+ |
+ |
− |
− |
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CD34 |
+ |
+ |
− |
− |
− |
− |
− |
− |
− |
− | − | ||
|
CD38 |
− |
+ |
+ |
− |
− |
− |
− |
− |
− |
− | + | ||
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CD40 |
− |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | |||
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CD43 |
+ |
+ |
+ |
+ |
− |
− |
− |
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CD45R |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | |||
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HLA-DR |
− |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ | − | ||
| AID | − | − | − | − | − | − | − |
− |
+ |
− | − | ||
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IL-7Rα |
− |
+ |
+ |
+ |
+low |
− |
− |
− |
− |
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| FLT3 | + | + | − | − | − | − | − |
− |
− |
| Summarized by: Zenggang Pan, MD, PhD | |
| References | |
| Annu. Rev. Immunol.19:595–621 (2001) | |
| Immunological reviews. 175: 175-186 (2000) | |
| Nature review immunology. 6:107-116 (2006) | |