Immunophenotypic Profiles of Acute Leukemia

 

 

Uploaded: 2007-06-18, Updated: 2007-06-18

   
  ACUTE MYELOID LEUKEMIA

Blastic

NK-cell

Leukemia

B-ALL

T-ALL

M0

M1

M2

M2

(8;21)

M3

M4

Blasts

M4 Monocytes

M5

M6

M7

CD2 +/− +
CD3 +
CD4 +/− +/− +/− +/− +/− +/− + + −/+ + +/−
CD7 −/+ −/+ −/+ −/+ −/+ −/+ +/− +/− −/+ −/+ +/−
CD10 +/− −/+
CD11b + +
CD11c −/+ −/+ −/+ −/+ −/+ +/− + +
CD13 + + + + + + + +dim −/+
CD14 + +/−
CD16 −/+
CD19 + +
CD20
CD22 +/−
CD33 + + + + + + + +(bright) +(bright)
CD34 + + + + + +/− +/− +/− + +/−
CD41 +
CD45 + + + + + + + + + + +/− +
CD56 −/+ −/+ −/+ + −/+ −/+ +/− + −/+
CD61 +
CD64 −/+ −/+ −/+ −/+ −/+ −/+ + +/−
CD79a +
CD117 + + + + + + −/+ +(dim) +(dim)
HLA-DR + + + + + + +/− + −/+ +(dim) +/− −/+
TdT −/+ −/+ −/+ −/+ −/+ + +/−
GPHA +
cIgM +/−
MPO + + + + + +  
NSE + + +  
PAS +/− +/− +/− + +/−   −/+ −/+
  M0: Acute myeloid leukemia, minimally differentiated   M1: Acute myeloid leukemia without maturation
  M2: Acute myeloid leukemia with maturation   M2: Acute myeloid leukemia with maturation with t(8;21)
  M3: Acute promyelocytic leukemia, hypergranular type   M3: Acute promyelocytic leukemia, microgranular type
  M4: Acute myelomonocytic leukemia   M4EO: Acute myelomonocytic leukemia with increased marrow eosinophils
  M5a: Acute monoblastic leukemia   M5b: Acute monocytic leukemia with maturation
  M6: Erythroleukemia (Erythroid /myeloid)   M6: Pure erythroid malignancy
  M7: Acute megakaryoblastic leukemia   M7:

Acute megakaryoblastic leukemia associated with t(l;22)

  Summarized By: Zenggang Pan, MD, PhD