|
Gene Translocations In Leukemia And Lymphoma |
||
|
|
Uploaded: 2007-12-07, Updated: 2007-12-07 |
|
|
Tumor |
Translocation |
Fused Gene |
|
| Anaplastic large cell lymphoma | t(2;5)(p23;q35) | 70-80% | NPM-ALK |
| t(1;2)(q25;p23) | 20% | TPM3-ALK | |
| Burkitt's lymphoma | t(8;14)(q24;q32) | 60-70% | IgH-cMYC |
| t(8;22)(q24;q11) | 10-15% | IgL-cMYC | |
| t(2;8)(p12;q24) | 2-5% | IgK-cMYC | |
| Follicular lymphoma | t(14;18)(q32;q21) | 80-90% | IgH-BCL2 |
| t(2;18)( p11;q21) | IgL-BCL2 | ||
| t(18;22(q21;q11) | IgK-BCL2 | ||
| Lymphoplasmacytic lymphoma | t(9;14)(p13;q32) | 50% | IgH-PAX5 |
| Mantle cell lymphoma | t(11;14)(q13;q32) | 50-70% | IgH-BCL1 |
| MALT lymphoma/marginal zone lymphoma | t(11;18)(q21;q21) | 20-50% | API2-MLT |
| t(14;18)(q32;q21) | 10-20% | IgH-MLT1 | |
| t(1;14)(p22;q32) | 5-10% | IgH-BCL10 | |
| t(3;14)(p14;q32) | 10% | IgH-FOXP1 | |
| Acute promyelocytic leukemia | t(15;17)(q22;q12) | 98% | PML-RARA |
| Chronic myelogenous leukemia | t(9;22)(q34;q11) | 100% | BCR-ABL |
| List of Genes Involved in Translocation | ||
|
Gene |
Aliases |
Location |
Function |
|
ALK |
2p23 |
Membrane associated TKR; probable role in the nervous system development and maintenance |
|
|
TPM3 |
NEM1 |
1q25 |
Actin-binding proteins, component of cytoskeletal microfilaments; mediate the effect of Ca2+ on the myosin-actin interaction |
|
NPM1 |
NPM |
5q35 |
RNA binding nucleolar phosphoprotein, involved in preribosomal assembly; transport ribonucleoproteins between cellular compartments |
|
C-MYC |
8q24 |
b-HLH-Zip transcription factor, activate transcription and promote cell proliferation and transformation |
|
|
BCL2 |
18q21 |
Antiapoptosis by forming complexes with caspase-9 and APAF1 |
|
|
IgH |
14q32.33 |
Immunoglobulin heavy chains |
|
|
BCL1 |
Cyclin D1 |
11q13 |
Role in the cell cycle control, G1 progression and G1/S transition |
|
PAX5 |
BSAP |
9p13 |
Required for B cell lineage commitment during early B cell development and also for B lineage maintenance |
|
BIRC3 |
API2 |
11q21 |
Member of the 'inhibitor of apoptosis' (IAP) protein family. Binds to the tumor necrosis factor receptor via its associated factors TRAF1 and TRAF2 and inhibits apoptosis, probably by interfering with activation of caspaces. |
|
MALT1 |
MLT |
18q21 |
|
|
BCL10 |
CARMEN |
1p22 |
A caspase recruitment domain; role in the apoptosis |
|
FOXP1 |
QRF1 |
3p14.1 |
Transcription factor; member of the FOXP subfamily, characterized by a DNA binding forkhead |
|
PML |
MYL |
15q22 |
Nuclear protein; contains zinc fingers and a leucine zipper; transcription factor. |
|
RARA |
|
17q12-21 |
Nuclear receptor; binds HRE, igand and dimerization domain; role in growth and differentiation. |
|
ABL |
ABL1 |
9q34 |
Nuclear c-ABL plays a major role in the regulation of cell death after DNA damage. Cytoplasmic c-ABL possibly functions in adhesion signaling. |
|
BCR |
PHL |
22q11 |
Protein kinase; probable role in signal transduction |
| REFERENCES |
|