Neuroendocrine Tumors of the Lung
 

 

Uploaded: 2008-04-28, Updated: 2008-04-28

 

 

Typical carcinoid

Atypical carcinoid

Small cell carcinoma

Large cell NE carcinoma
Grade Low grade Intermediate grade High grade High grade
Age (yrs) 50 54 62 63
Sex (M:F) 1:1 1:1 2:1 4:1
Nonsmokers (%) 44 37 0 0
Organoid pattern Yes Yes   Yes
Mitoses (/10HPF) 0–1 2–10   >10
Necrosis No Yes Yes Yes
Nuclear atypia Uncommon Common Prominent Prominent
Cytoplasm Moderate Moderate Little Abundant
Chromatin Finely granular Finely granular Finely granular Finely granular
Nucleoli Inconspicuous Inconspicuous Inconspicuous Prominent
Regional LN metastasis Up to 15% Up to 50%    
Distant metastasis Rare Up to 10%    
Surgery Primary approach Primary approach Controversial If resectable
Chemotherapy Not proven Not proven Primary approach Promising
Radiation Not proven Not proven Effective locally Effective locally
5-year survival >87% 61% 9 to 25% 27%
10-year survival >87% 35% 5% 9%

REFERENCES

  • Ann Thorac Surg 2003;75:348-352

  • Ann Thorac Surg 2007;84:702–7

  • Modern Pathology (2006) 19, 1358–1368

  • Curr Opin Pulm Med 2002, 8:275–280