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Papillary Urothelial Neoplasm of Low Malignant Potential |
Urothelial Carcinoma Low Grade |
Urothelial Carcinoma High Grade |
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Architecture |
Delicate, papillary, preserved architecture |
Papillary, fused, branching, loose clusters |
Fused, papillary, flat, nodular or isolated |
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Cell Organization |
Even, not dense, cohesive, ordered |
Mainly even, cohesive, ordered Slightly dense, loss of order |
Often disordered, loss of polarity, dyscohesive |
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Umbrella Cells |
Well preserved |
Partially preserved |
Often not present |
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Cell Number |
Normal or slightly increased |
Often numerous |
Variable |
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Cell Size |
Increased, uniform |
Increased, uniform |
Increased, pleomorphic |
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Cell boarder |
Moderately distinct |
Indistinct |
Indistinct |
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Cytoplasm |
Reduced cytoplasmic clearing |
Homogeneous, no cytoplasmic clearing |
Variable, common vacuolization |
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N/C Ratio |
Increased |
Increased |
Increased |
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Nuclei |
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Position |
Perpendicular orientation, eccentric |
Eccentric |
Eccentric |
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Size |
Maybe uniformly enlarged |
Enlarged with slight variation in size |
Enlarged with variation in size |
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Morphology |
Round, elongated or oval, uniform |
Round or slightly pleomorphic |
Moderate-marked pleomorphism |
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Border |
Regular or irregular |
Irregular |
Irregular |
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Chromatin |
Evenly dispersed and finely granular |
Evenly dispersed, mild variation |
Hyperchromasia, coarse granularity |
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Nucleoli |
Small or absent. |
Inconspicuous or large |
Variable, often prominent |
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Mitosis |
Present, but not numerous, basal |
Maybe common, not important |
Common and abnormal |
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Behaviors |
No invasion or metastasis |
Can invade but rarely metastasize |
Often infiltrate |
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Histology |
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Lower power |
PUNLMP (AFIP, series 4) |
Urothelial carcinoma, low grade (AFIP, series 4) |
Urothelial carcinoma, high grade (AFIP, series 4) |
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Higher power |
PUNLMP (AFIP, series 4) |
Urothelial carcinoma, low grade (AFIP, series 4) |
Urothelial carcinoma, high grade (AFIP, series 4) |
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Cytology |
PUNLMP (AFIP, series 4) |
Urothelial carcinoma, low grade (AFIP, series 4) |
Urothelial carcinoma, high grade (AFIP, series 4) |
