Case 9 - Discussion

Uploaded: 2007-01-14, Updated: 2007-12-07

Clues to Drug Reactions

• Hyperkeratosis, parakeratosis;

• Superficial dermal edema and spongiosis;

• Apoptotic keratinocytes or individual keratinocytic necrosis;

• Superficial perivascular lesions with exocytosis of lymphocytes, eosinophils and/or plasma cells;

• Endothelial swelling of vessels;

• Nuclear dusts and red cell extravasation.

Superficial and Deep Inflammation of the Skin (8Ls+DRUGS)

• Light reaction;

• Lymphoma;

• Leprosy;

• Lues;

• Lichen stratus;

• Lupus erythematosus;

• Lipidica (Necrobiosis);

• Lepidoptera (and other arthropods)

• Dermatophyte

• Reticular erythmatous mucinosis;

• Urticarial stages (BP);

• Gyrate erythemas;

• Scleroderma;

• Drug reactions.