Case 11 - Discussion

Uploaded: 2007-01-18, Updated: 2007-06-22

Kappa, ISH, 4 Lambda, ISH, 4
BCL2, IPX, 4  

Nodular lymphoid hyperplasia (NLH) of the GI

Clinical Futures
  • Most frequent symptoms: diarrhea, involuntary weight loss and abdominal pain.

  • Associated with immunodeficiency: common variable immunodeficiency (CVI), AIDS.

  • Increased risk of gastrointestinal tumors, mainly gastrointestinal lymphoma

  • Hermanís syndrome: NLH, hypogammaglobulinemia and Giardia lamblia infection.
Gross Findings
  • May resemble small adenomatous polyps on gross examination.
Microscopic Findings
  • Hyperplasic lymphoid follicles with mitotically active germinal centers at mucosa and/or submucosa.

  • The number of follicles is not a diagnostic criterion.

  • World J Gastroenterol. 2006 March 28; 12(12): 1945-1948