In immunocompentent individuals,
most CMV infections are mild and may produce a viral syndrome
resembling infectious mononucleosis.
CMV is the most common
infection in solid organ transplants, with over half of the
patients showing evidence of active CMV infection.
The white cells of 5% of blood
donors contain CMV, therefore infection by blood transfusion
occurs in a large number (60%) of patients.
CMV can infect epithelial cells of
the airways and alveoli, fibroblasts, macrophages and
endothelial cells. Typical
intranuclear inclusion body shows a bull-eye appearance with a