Case 36 - Discussion

Uploaded: 2007-03-26, Updated: 2007-06-22

CK 5/6,  20 EGFR, 20
 
CD14, 20  
Actin, 20, tumor Actin, 20, normal ducts in the same case
Caldesmon, 20, tumor Caldesmon, 20, normal ducts in the same case
Desmin, 20, tumor Desmin, 20, normal ducts in the same case
Myogenin, 20, tumor Myogenin, 20, Positive control
p63, 20, tumor p63, 20, normal ducts in the same case
SMM, 20, tumor SMM, 20, normal ducts in the same case
SMA, 20, tumor SMA, 20, normal ducts in the same case
   
 

 

  RIGHT BREAST, LUMPECTOMY:
- Infiltrating ductal carcinoma, basaloid subtype, maximum tumor size, 1.5 cm.
- Histopathologic grade (MSBR): Intermediate, 2/3.
- All margins negative for malignancy; Distance from closest margin: 5mm.
- Lymphovascular invasion identified.
- Histopathologic stage (TNM): pT1c, pN0, pMX; stage I.
- Other findings:
     - Ductal hyperplasia without atypia.
     - Fibrocystic change.
     - Lymphocytic reaction is noted around the malignancy.
   
 
Immunohistochemistry Stains:
- ER-Negative
- PR-Negative
- Her2/Neu - Borderline
- Ki-67-Positive
- CK5/6-Focally positive
- CK14-Positive
- EGFR-Positive
Smooth muscle/myoepithelium markers:
- Actin, postive
- Caldesmon, weakly positive
- Desmin, focally positive
- Myogenin, weakly positive
- p63,focally weakly positive
- SMM, positive
- SMA, positive
HER2/neu is not amplified by FISH.