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Benign Brenner tumor of the right
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CLINICAL FEATURES |
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- An ovarian transitional cell
tumor composed of mature urothelial-like cells arranged in solid
or cystic aggregates within a predominantly fibromatous stroma;
- 4-5% of benign ovarian
epithelial tumor, 30-60 year-old;
- Mostly asymptomatic, <2cm,
discovered incidentally;
- Occasionally secretion of
estrogen or androgen by the stromal component.
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GROSS FINDINGS |
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- Small, often <2cm, well
circumscribed with a firm, white and gritty sectioned surface
due to calcification;
- Often small cysts;
- 25% cases associated with
mucinous cystadenoma.
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MICROSCOPIC FINDINGS |
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- Transitional epithelial cells
in nests and islands, solid or central lumen with dense
eosinophilic mucin+ material;
- The lumen may be lined by
transitional cells, mucinous, ciliated or nondescript columnar
cells;
- The epithelial cells have
centrally located, grooved, "coffee bean" nuclei, and abundant
amphophilic to clear cytoplasm with distinct cellular borders;
- Prominent fibromatous stroma.
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SUBTYPES |
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DIFFERENTIAL DIAGNOSES |
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- Borderline Brenner tumor:
atypical or malignant epithelium, but no obvious invasion;
- Malignant Brenner tumor:
invasive TCC or SCC and benign or borderline tumor in a
fibromatous stroma.
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IMMUNOHISTOCHEMISTRY AND SPECIAL STAINS |
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- Epithelial cells uroplakin
positive
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ELECTRON MICROSCOPIC FINDINGS |
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CYTOGENETIC STUDIES |
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TREATMENT AND PROGNOSIS |
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REFERENCES |
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- WHO Classification, Tumor of
the Breast and Female Genital Organs, IARC, 2003
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