Case 83 - Discussion

Uploaded: 2007-08-26 Updated: 2007-08-28

   
 

Angiosarcoma of the Scalp

CLINICAL FEATURES
 
GROSS FINDINGS
 
MICROSCOPIC FINDINGS
 
  • Early lesions may show benign capillary hemangioma-like structures; Often show extensive involvement of the dermis and even deep structures such as fascia and subcutis; Three histologic patterns: vascular channels, sheets of cells, and cells of undifferentiated morphologic features.
SUBTYPES
 
DIFFERENTIAL DIAGNOSES
 
  • Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma;
  • Hemangiomas
IMMUNOHISTOCHEMISTRY AND SPECIAL STAINS
 
  • Positive: von Willebrand factor (vWF), CD31 and CD34
ELECTRON MICROSCOPIC FINDINGS
   
CYTOGENETIC STUDIES
   
TREATMENT AND PROGNOSIS
 
REFERENCES
 
  • www.emedicine.com/plastic/topic494.htm
  • Cutaneous Angiosarcoma of the Scalp. Cancer 2003;98:1716–26
  • AFIP, series 4. Nonmelanocytic Tumor of the Skin.
  • European Journal of Dermatology. Volume 11, Number 3, 261-3, May - June 2001
  • Am J Dermatopathol 2007;29:342–350)
  • Cutaneous Angiosarcoma. American Journal of Clinical Oncology • Volume 29, Number 5, October 2006