Case 92 - Discussion

Uploaded: 2007-09-07 Updated: 2007-09-07

   
DESMIN KI67
PAN-CK S100
SMA

SMM

 
VIMENTIN  
   

 

The tumor is diploid.

 

CYTOGENETICS REPORT

NOMENCLATURE: 46,XX[32]

Cytogenetic analysis did not reveal any evidence of a consistent detectable numerical or structural chromosomal anomaly at this band level.

  Monomorphic Adenoma (Benign Myoepithelioma) of Parotid Gland
 
  • Benign tumor, consists of sheets and islands of various proportions of spindle, plasmacytoid, epitheloid, oncycytic and clear cells that exhibit myoepithelial but not ductal differentiation;

  • Rare or no ducts;

  • May have abundant, acellular, mucoid, or hyalinized stroma, but no chondroid or myxochondroid foci;

  • Reactive to cytokeratin, SMA, S100, GFAP and vimentin;

  • DDX: mixed adenoma, nerve sheath tumor, fibrous histiocytoma, nodular fasciitis, leiomyoma, and synovial sarcoma.