Case 143 - Discussion

Uploaded: 2007-11-04, Updated: 2007-11-04

   
 

ELECTRON MICROSCOPY
Ultrastructurally, the neoplasm consists of sheets of neoplastic spindle-shaped cells embedded in a collagen-like matrix. The neoplastic cells contain long, spindly, irregular nuclei with chromatin clumping and occasional prominent nucleoli. The neoplastic cell cytoplasm contains abundant rough endoplasmic reticulum with occasionally dilated cisterna. Some of the cells have intermediate filaments with dense bodies approximating the plasma membrane. Pinocytic vacuoles are inconspicuous. A very occasional lipid vacuole is noted within these cells. Intermixed amongst the neoplastic cells are macrophages and occasional capillary. No mitotic figures are noted. ULTRASTRUCTURAL IMPRESSION: Spindle cell neoplasm.
 

CYTOGENETICS REPORT

NOMENCLATURE: 48,XX,dup(4)(p13p15.1),+18,+der(22)r(22;17;?)(p12q13;q21q25;?)[20]
Cytogenetic analysis revealed the presence of a hyperdiploid clone characterized by a duplication of a portion of 4p, trisomy 18, and a supernumerary ring chromosome comprised of 22q, 17q and unknown material. These findings, specifically the presence of the ring chromosome, support the clinical diagnosis of dermatofibrosarcoma protuberans.

 

Dermatofibrosarcoma Protuberans

 
CLINICAL FEATURES
   
GROSS FINDINGS
   
MICROSCOPIC FINDINGS
   
SUBTYPES
   
DIFFERENTIAL DIAGNOSES
   
IMMUNOHISTOCHEMISTRY AND SPECIAL STAINS
   
ELECTRON MICROSCOPIC FINDINGS
   
CYTOGENETIC STUDIES
   
TREATMENT AND PROGNOSIS
   
REFERENCES