Case 257 - Discussion

Uploaded: 2008-08-24, Updated: 2008-08-24

Lobular Carcinoma of Breast

Microscopically, the tumor extensively invades all four quadrants of the breast, including the nipple and also the deep margin. The dyshesive tumor cells are frequently arranged in single lines or concentrically surrounding the vessels or ducts. Individual tumor cells are intermediate in size with small to moderate clear cytoplasm. The nuclei are round or angular with open chromatin and one centrally localized small nucleolus. Frequent perineural invasion is present.