Rarely secrete hormonal
products and cause clinical symptoms.
similar to other breast cancers without distinctive clinical or
appearances. Argyrophilic carcinomas represent a heterogeneous
group of tumors, and the true endocrine differentiation is deﬁned
by immunostainsfor endocrine markers.
No overt morphologic
evidence of endocrine differentiation but show endocrine
differentiation by IHC; or
suggestive but not diagnostic of endocrine differentiation; or
Organoid growth pattern with
uniform epithelioid or spindle cells arranged in trabeculae and
Some tumors with typical
endocrine morphology fail to show histochemical evidence of
DDX: metastatic carcinoids.
IHC: Usually ER+,
PR+ and lack of HER2 over-expression.
Prognosis: similar to
invasive ductal carcinoma, NST.