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Case 281 - Discussion

Uploaded: 2009-02-22, Updated: 2009-02-22



EBV-ISH Positive
Undifferentiated Nasopharyngeal Carcinoma
  • Syncitial growth pattern with indistinct cell margins.

  • Often accompanied by prominent inflammatory reaction with lymphocytes.

  • Vesicular nuclei with a smooth outline and a single, large, sharply etched eosinophilic nucleolus.

  • EBV positive. Keratin and EMA positive.

  • Most common initial presentation: unilateral cervical lymphadenopathy.

  • Very sensitive to radiation therapy with a complete remission rate of 83%.

  • keratinizing type has the worst prognosis.


  • Rosai and Ackerman's Surgical Pathology, 9th edition