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Also called monomorphic adenoma
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Adult, slightly
female predilection, mostly in parotid gland.
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Grossly,
encapsulated,
often cystic, relatively small.
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Microscopic:
solid, trabecular or tubular growth of epithelial cells; peripheral palisading;
abundant basal lamina material around and within the tumor
nests; occasional acinar cells, squamous
whorls or keratinization; no invasion, mesenchymal component or myxoid matrix.
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Associated with
multiple dermal cylindroma and 16q abnormality.
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IPX: ductal cells
-keratin, alpha-1-antichymotrypsin, CEA, S100 (alpha
subunit); basaloid cells - vimentin, actin, S100 (beta
subunit)
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Canalicular
adenoma, a variant of basal cell adenoma, bilayered strands
or ribbons of columnar cells sperated by loose
well-vascularized stroma. Mostly in minor salivary glands.
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