Back to Homepage

Case 282 - Discussion

Uploaded: 2009-02-18, Updated: 2008-02-18

Basal Cell Adenoma

  • Also called monomorphic adenoma

  • Adult, slightly female predilection, mostly in parotid gland.

  • Grossly, encapsulated, often cystic, relatively small.

  • Microscopic: solid, trabecular or tubular growth of epithelial cells; peripheral palisading; abundant basal lamina material around and within the tumor nests; occasional acinar cells, squamous whorls or keratinization; no invasion, mesenchymal component or myxoid matrix.
  • Associated with multiple dermal cylindroma and 16q abnormality.
  • IPX: ductal cells -keratin, alpha-1-antichymotrypsin, CEA, S100 (alpha subunit); basaloid cells - vimentin, actin, S100 (beta subunit)
  • Canalicular adenoma, a variant of basal cell adenoma, bilayered strands or ribbons of columnar cells sperated by loose well-vascularized stroma. Mostly in minor salivary glands.

REFERENCES

  • Rosai and Ackerman's Surgical Pathology, 9th edition