-
Rare tumor, 1/1M; 40-50 years.
-
Common complain, abdominal or flank
pain.
-
Can cause Cushing's syndrome,
virilization. Malignant tumors are more often non-functional.
-
500-1300 grams, average size 15 cm.
-
Gross: may be encapsulated and
lobulated; cut surface, nodular, yellow-orange to tan, often
necrosis and hemorrhage.
-
Micro:
-
Various patterns. Most common
pattern: broad anastomosing trabeculae surrounded by
sinusoids. Other patterns: alveolar, solid, diffuse. Other
findings: spindle foci, myxoid or mucinous stroma.
-
Cytoplasm: abundant, granular,
eosinophilic or clear.
-
Mitoses, maybe numerous and
atypical.
-
Diagnostic features: vascular
invasion, capsular invasion, and extension into the adipose
tissue.
-
IPX: vimentin +, inhibin +, CK-
|