Back to Homepage

Case 369 - Discussion

Uploaded: 2009-10-21, Updated: 2009-10-26

 

Mucinous Tubular and Spindle Cell Carcinoma of Kidney (MTSCC)

 

CLINICAL FEATURES

  • A uncommon pattern of RCC, possible of collecting duct and possibly loop of Henle origin.

  • Predominantly in females.

  • Not associated with malignant behavior.

GROSS FINDINGS

  • Solid, pale tan to yellow to gray-white;

  • May have slight focal areas of necrosis or hemorrhage.

MICROSCOPIC FINDINGS

  • Elongated branching tubules in a bubbly myxoid stroma.

  • Collapsed tubules in a cord-like pattern.

  • The cells are cuboidal, with scant, clear to pale, acidophilic cytoplasm and low-grade nuclear features.

  • The background is mucinous with basophilia and a characteristic bubbly appearance.

IMMUNOHISTOCHEMISTRY AND SPECIAL STAINS

  • Cytokeratins 18 and 19, and EMA

CYTOGENETIC STUDIES

  • Consistent losses of chromosomes 1, 4, 6, 8, 9, 13, 14, 15, and 22.

REFERENCES

  • AFIP, tumor of the kidney, bladder and related urinary structures, series 4