Back to Homepage

Case 401 - Discussion

Uploaded: 2010-07-15, Updated: 2010-07-15


Chondroid Lipoma

  • Mostly female, slow growing, painless, benign

  • Micro:

    • Well circumscribed, mixture of vacuolated cells, prominent chondromyxoid matrix and variable mature fat

    • No pleomorphism, atypia, atypical mitotic activity, or mature hyaline cartilage

    • May show hemorrhage and fibrosis

  • IPX: S100+ in lipoblasts and adipocytes

  • DDX:

    • Myxoid liposarcoma: chicken-wire vasculature,  no prominent cords or clusters of cells, t(12;16)

    • Extraskeletal myxoid chondrosarcoma: prominent fibrous septa, chondroblasts without  intracytoplasmic vacuoles, no mature fat, frequently mitoses and necrosis


  • Enzinger and Weiss's Soft Tissue Tumors, 5th Edition. By Drs. Sharon Weiss and John Goldblum. 2007