-
Rarely secrete hormonal
products and cause clinical symptoms.
-
Clinical presentation
similar to other breast cancers without distinctive clinical or
mammographic features.
-
Variable histologic
appearances. Argyrophilic carcinomas represent a heterogeneous
group of tumors, and the true endocrine differentiation is defined
by immunostainsfor endocrine markers.
-
No overt morphologic
evidence of endocrine differentiation but show endocrine
differentiation by IHC; or
-
Histologic features
suggestive but not diagnostic of endocrine differentiation; or
-
Organoid growth pattern with
uniform epithelioid or spindle cells arranged in trabeculae and
ribbon-like configurations.
-
Some tumors with typical
endocrine morphology fail to show histochemical evidence of
argyrophilia.
-
DDX: metastatic carcinoids.
-
IHC: Usually ER+,
PR+ and lack of HER2 over-expression.
-
Prognosis: similar to
invasive ductal carcinoma, NST.
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