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Case 437 - Discussion

Uploaded: 2010-10-09, Updated: 2010-10-09

 

 

Merkel Cell Carcinoma

The Key Features

  • Small blue round uniform tumor cells;

  • CK20, Perinuclear globules.

Clinical Futures

 
  • Also named primary neuroendocrine carcinoma of the skin;

  • Predilection for the head and neck of older adults, sun-exposed area;

  • Distant metastasis in 40% patients.

Gross Findings

 
  • Pink-red or violaceous, firm, dome-shaped solitary rapidly growing nodule.

Microscopic Findings

 
  • Sheet-like, nested, trabecular growth

  • Monotonously uniform, small, round to oval; finely dispersed chromatin; nucleoli not prominent; Scant cytoplasm and faintly amphophilic;

  • Abundant mitoses; Extensive necrosis and individual cell necrosis;

  • Delicate fibrovascular stroma.

Differential Diagnosis

 

Tumor

PanCK CK20 CK5/6 P63 TTF1 CD99 CEA S100

Melan-A

Vimentin

CD45

Merkel cell carcinoma + + +/−
Metastatic small cell carcinoma (lung) + + +/− +/−
Small cell squamous carcinoma + + + +/−
Small cell eccrine carcinoma + +/− +/− +/−
Small cell melanoma +/− + + +
Primitive neuroectodermal tumor +/− + +
Non-Hodgkin's Lymphoma +/− +/− +

Immunohistochemistry Straining

 
  • Perinuclear globule with low molecular weight CK;

  • Positive: CK20, NSE, chromogranin, synaptophysin, somatostatin, calcitonin, VIP, CD117;

  • Negative: S-100, CEA, TTF1

Election Microscopy

 
  • Paranuclear whorls of intermediate filaments;

  • Membrane-bound dense-core secretory granules.

Treatment and Prognosis

 
  • Very aggressive tumor.

Reference

 
  • AFIP, non-melanocytic tumors of the skin, series 4;