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Case 466 - Discussion

Uploaded: 2011-10-27, Updated: 2010-10-27


The spindle cells are positive for vimentin and cytokeratin.


Metaplastic Carcinoma of Breast

  • Heterogeneous neoplasm: adenocarcinoma and other component (squamous, spindle, chrondroid, osseous differentiation).

  • More aggressive than invasive ductal carcinoma; usually hematogenous metastasis, not nodal.

  • Vimentin in mesenchymal elements.

  • Keratin (broad spectrum or 34betaE12) in spindle or epithelial cells.

  • ER-, PR-, HER2-