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Case 476 - Discussion

Uploaded: 2011-02-18, Updated: 2011-02-18

 

Synaptophysin

Synaptophysin

 

Neuroendocrine Nests (Residual Islets)

  • The irregular cell nests associated with IPMN reveal pleomorphism and hyperchromasia. They are entrapped pancreatic islets due to the chronic pancreatitis associated with IPMN. Similar morphologic changes can be noted in the adjacent lobules.

  • Be aware of the reactive pancreatic ducts and islets, both of which may mimic invasive adenocarcinoma.