A rare subtype of undifferentiated carcinomas, composed of islands of atypical,
large, epithelial cells accompanied by a benign dense lymphoplasmacytic infiltrate.
Particularly frequent among Eskimos and Chinese.
Often metastasize to regional lymph nodes or distant organs,
particularly lung, liver, and bone.
Histology: mixture of epithelial
solid islands and reactive lymphoid tissue; the epithelial
component mostly consists of non-keratinizing large cell carcinoma
with occasional spindle-shaped areas.
- Cytokeratin positive and often EBV positive