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Case 485 - Discussion

Uploaded: 2011-04-25, Updated: 2011-04-25

 

PAS-D

PAS-D

PAS-D

Alpha 1 antitrypsin immunostain

 

 

 

α1-antitrypsin deficiency

  • AR, Chromosome 14, PiSZ, PiSS, PiMZ.

  • PiZZ most common, worst prognosis.

  • Periportal PAS/D+ inclusions, 1-10um.

  • Cholestatic changes and hepatitic changes

  • Pulmonary emphysema, cirrhosis and HCC