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Case 508 - Discussion

Uploaded: 2011-07-21, Updated: 2011-07-21

 

Wegener’s Granulomatosis

  • M > F, 40-50 yo

  • Upper respiratory tract, lung, kidney

  • HE:

    • Collagen necrosis

    • Palisaded granuloma/microabscess

    • Segmental vasculitis

    • Geographic necrosis → cavitation

    • Marked background inflammation

  • cANCA (PR3) +, > 90%