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Case 516 - Discussion

Uploaded: 2011-08-19, Updated: 2011-08-19

 

Cytokeratin

Cytokeratin

CD45

CD45

 

 

 

Lymphocytes with Signet-Ring Cell Features

  • In extraordinary circumstances, reactive or neoplastic lymphocytes may show prominent signet-ring cell features, which may resemble signet-ring carcinoma. In this case, these signet-ring lymphocytes can mimic prostatic adenocarcinoma with signet-ring cell features.

  • BTW, prostatic adenocarcinomas are graded based on the architecture, not cytology. The signet-ring cells in these cases are mucicarmine negative.